Little did I know that, in the course of researching for that post, I would come across an episode of Explorer seemingly even more precisely relevant to ponerology than that. But that is just what happened.

Ponerology is defined as “the science of evil.” And, to my surprise, I came across a 2008 episode of Explorer actually entitled “Science of Evil.”

Just as in “Born to Rage,” the main framework for this episode’s exploration is established by the narrator early on. This time the guiding quote is this:

“Evil. It is blamed for cruelty beyond our mind’s comprehension. Is it a dark force outside of us that we are all vulnerable to, that we must work to resist? Is it inside of us, a stain on the soul, a dysfunction of the brain? Or just a word used to distance ourselves from inherently human behavior?”

Part 1:

Part 2:

Part 3:

“Science of Evil” focuses on four stories:

• One of the “usual suspects” when discussing evil, Dr. Philip Zimbardo, gives a detailed chronology of the development of sadistic events in his famous Stanford prison experiment and discusses its relationship to the abuses at Abu Ghraib prison, after which he was called as an expert defense witness in the court martial of one of the accused American officers.
• We get a look at notorious serial killer Jeffrey Dahmer through the eyes of Reverend Roy Ratcliff, a minister who met with Dahmer at a maximum security prison in Wisconsin in 1994 to discuss the Bible and ultimately help fulfill Dahmer’s request to be baptized.
• Joshua Greene, an Assistant Professor of Psychology at Harvard, speaks about what defines evil and – along with colleague Jonathan Cohen of Princeton’s Center for the Study of Brain, Mind and Behavior – introduces us to their fMRI research, imaging people’s brains during moral decision-making to determine the sometimes conflicting neurological processes involved in our sense of right and wrong.
• We follow Aya Schneerson of the United Nations’ World Food Program as she reveals through her work some of the atrocities she has witnessed in the course of distributing food in war-torn Eastern Congo that she considers evil.

As these stories play out, we are led to consider how situational and neurological factors can both play roles in the development of behavior often deemed evil and the implications of what we may discover as we continue teasing apart their relative contributions to the harm and suffering in our world.

National Geographic Explorer’s “Science of Evil” provides a rather cursory overview of some of the questions involved in ponerology. It doesn’t do nearly as much to provide answers to those questions as some of the other resources featured on this site do. But it may, nonetheless, inspire curiosity in a newcomer to these issues.

I write frequently about the fact that, despite the increased level of attention to it that we document here, this topic, the science regarding malicious and neglectful activity – a.k.a. the “science of evil” – is vastly under-discussed and under-promoted in our society. The fact that even I, having researched and written about this topic for years, was unaware until now that this episode of Explorer even existed offers just one more illustration of that. But hopefully, sharing it here will enable it to reach a few more people who will share it with those they know and so on.

Dr. Kent Kiehl of the Mind Research Network has been one of the more active researchers investigating what we can learn from brain imaging of psychopaths. And he and colleagues have recently published, in the Proceedings of the National Academy of Sciences of the United States of America, a study entitled “Neuroprediction of future rearrest.”

The study involved having 96 soon-to-be-released male prisoners perform computer tasks that required quick decision-making and inhibition of impulsive responses, while their brains were observed using functional magnetic resonance imaging (fMRI). The researchers focused in on the brain region known as the anterior cingulate cortex (ACC) and found that, when controlling for other known risk factors, those prisoners with less ACC activity than their fellow study participants were about twice as likely to be rearrested within 4 years of release as those with higher ACC activity.

We’ve already mentioned, in previous stories, that reduced cingulate cortex function is associated with psychopathy and has been identified in some violent criminal offenders.

The question is, as we zero in on markers like this – whether they be certain anatomical or functional characteristics of the brain, particular genetic features or anything else – what is the most ethical way in which to use this knowledge?

On one hand, it could be considered highly unethical and dangerous to discriminate against, detain or punish anybody – even a previous offender – simply because they happen to exhibit particular biological markers if those markers have not expressed themselves in a specific behavior for which they are being criminally charged. Beginning to do so could open the door to frightening abuses by authorities.

Most of the commenters on the Daily Mail’s story about this study fell on this side of the issue and raised such concerns.

For example, “Dunnyveg” said:

“Actually, low IQ, high testosterone, and a record of previous convictions are the best indicators for recidivism; there is no need for fancy technology. But none of these absolve society from our time-honored principle of innocent until proven guilty. Talk about a potential totalitarian nightmare, this is it….”

“Percival” said:

“Still like technology gullible science fans? Little do you realise these are not to benefit you but to control you, all of it is too control and watch and report back and have you slaves to the system.”

Martin said:

“Well that fills the biggest gap left in achieving the full ’1984 infrastructure’ now they’re rolling out internet TVs that watch you and listen to you (and that some mugs are actually buying) – welcome to the world of ‘thought crime’ ….”

The very idea of predicting and preemptively acting to prevent crimes before they are committed reminds many of the brilliant Philip K. Dick story, later made into a movie by Steven Spielberg, “The Minority Report.”

On the Daily Mail article, “Jeff Pringle” commented:

“Minority Report anyone?”

And Nature began their story on the study with “In a twist that evokes the dystopian science fiction of writer Philip K. Dick…” and, later in the article, mentioned “The Minority Report.”

But, on the other hand, it could be considered unethical not to use our improving predictive ability if failing to do so allows offenders to cause harm and suffering to others that could have, with minimal collateral damage, been prevented. How would you feel if a loved one was harmed by a person who we knew ahead of time, based on various markers and indicators, had an extremely high likelihood of offending but did nothing to stop?

Some may take comfort in the fact that we can, for the moment, postpone fully grappling with these dilemmas. Our predictive ability based on markers like those in Kiehl’s study is still poor enough that it seems clearly unreasonable, at the present time, to base highly consequential legal actions on it alone. Even Kiehl himself concedes as much.

But as our knowledge and technology improve, there may well come a day when the gap between the pros and cons of applying them to predict and prevent crime narrows. Eventually, we may have to decide at exactly which threshold level of predictive reliability it becomes more unethical, even in the face of potential unintended consequences, to allow a person marked as extremely likely to cause harm to act freely than to take action to reduce the threat they pose. The decision about where to draw such a line could arouse furious debate.

One commenter on the Nature article, “Mitch Trachtenberg,” offered a nice middle ground where many of us, despite different viewpoints on the matter, may frequently find ourselves able to meet, when he said:

“This knowledge could be abused by someone refusing to release someone on parole or probation due to “unacceptable-ACC-levels.” But it could really be helpful if the results were used to get someone additional help or even monitoring. Helping people with problems controlling their impulses could be beneficial, and it would be great to have a way of discovering which people in our prison system might well be there for exactly that reason.”

Hopefully Mitch’s idea will prove prescient and we can find a way, at least much of the time, to use this knowledge and these tools in a compassionate way that aims to authentically help people, not just stigmatize or harass them. But it’s hard to imagine a future where we aren’t sometimes faced with incredibly difficult decisions about cases that just don’t allow for any easy middle ground where we can hide.

What are your thoughts on the subject?

How do you weigh the danger of authorities abusing these predictive abilities against the threat posed by individuals with biological markers associated with harming others?

What do you think is the most ethical way to deal with the dilemmas these predictive abilities may one day pose?

Let us know in the comments below.

Most who work in the fields that study aspects of this question take the view that the answer involves some combination of the two.

But this still leaves us with another question. In what proportion do each of these factors contribute in which people?

One remarkable case offers some fascinating insight on the subject.

Dr. James Fallon

James Fallon, Ph.D. is a highly decorated neuroscientist and Professor Emeritus of Anatomy and Neurobiology at University of California, Irvine. Dr. Fallon has several areas of expertise. One is adult stem cells. Another is psychiatry. Specifically, he is interested in the relationships between brain imaging (he has served as Director of UC Irvine’s Human Brain Imaging Center), genetics and various psychiatric conditions, including schizophrenia, depression and addictions.

An Extraordinary Experiment

Aware of his specialties, for many years, Fallon’s colleagues have sent him brain images they wished to have him analyze.

At one point this interchange took the form of an experiment.

Colleagues sent him 70 MRI scans of brains belonging to people ranging from healthy to mentally ill. Included in the batch were scans of brains belonging to killers, including some notorious ones. But Fallon had no idea which scanned brain belonged to whom.

Nonetheless, he was able to identify differences in five of the scans so dramatic that he could recognize them as the markers of psychopathy. And it turned out that he was correct. The five scans on which he zeroed in actually were those from the brains of psychopathic serial killers.

Signs of the Psychopath’s Brain

How could Fallon distinguish the serial killers’ brain scans from the others? He says that all five had some tell-tale signs:

• A lack of activity in the orbital cortex, the brain area just above the eyes, which he says is in the circuit coding for ethics, conscience and impulse control
• A lack of activity in the anterior part of the temporal cortex, where we find the amygdala, a structure deeply involved in processing emotion
• Underfunctioning in the narrow strip of limbic cortices that connect the orbital cortex with the amygdala, namely:
  • The cingulate cortex, which codes for social cues
  • The hippocampal area, which, along with the amygdala, codes for emotional memories
  • The insula, which processes empathy and “gut feelings”

This makes sense. These areas are considered part of the limbic system, the brain complex primarily responsible for our emotional lives. When these areas are underactive or inactive, a person might feel driven – like many killers – to compensate by repeatedly pursuing extreme activities simply to feel satisfied and alive.

Violence-Related Genes

In addition to his study of killers’ brains, Fallon has also studied the genetics of aggression and violence.

Psychological traits are affected by multiple genes. And Fallon says that perhaps a dozen have been identified as high-risk, violence-related genes. These include genes affecting dopamine and norepinephrine neurotransmission and androgen (testosterone) receptors.

The most well-known of these violence-related genes is a particular version of the Monoamine Oxidase A (MAOA) gene. Because it was the first such gene discovered, it was labeled, and has become popularly known as, “the Warrior Gene,” although Fallon stresses that this nickname can be misleading since all of the various genes associated with violence and aggression could be considered, in a sense, warrior genes.

Most humans have an MAOA gene and it helps regulate serotonin, a neurotransmitter that Fallon says helps relax and calm us. But those with the “Warrior Gene” form of it receive too much serotonin during development in utero, which desensitizes the brain to its effects. That means that later in life, when serotonin would otherwise inhibit behavior, it is unable to do so, resulting in impulsivity and violence.

The MAOA gene is on the X chromosome. This has important implications for how its effects express themselves in males vs. females. Girls get an X chromosome from both their mother and father, so even if one parent passes along the “Warrior Gene” variant, they are likely to get a normally functional MAOA variant from the other parent that offsets its potentially dangerous consequences. But boys get only one X chromosome – the one passed down from their mother. If that X chromosome has the “Warrior” version of the MAOA gene, that will be the only version of it that the boy receives.

This means that violence related to the MAOA “Warrior Gene” is usually passed genetically from mother to son. Fallon believes it also explains why boys and men are much more likely to be very aggressive or psychopathic killers.

Moreover, Fallon says that the reduced empathy seen in psychopathy may be associated with the influence of low acting genes related to the hormones oxytocin and vasopressin.

Can Biology Alone Create a Psychopath?

So, putting this together, Fallon recognized patterns in both the brains and genetics of psychopathic killers.

1. Loss of function in the orbital cortex, anterior temporal lobes and the strip of limbic cortices connecting the two
2. Having one or more of several high-risk, violence-related genes (like the so-called “Warrior Gene”)

But a crucial question remained. Are these biological markers alone enough to create a psychopath?

Fallon suspected not. But little did he know that he would receive some validation for this suspicion from so close to home.

A Shocking Fallon Family Pattern is Revealed

Based on his work, Fallon was giving many presentations about psychopathic killers. His mother said that, since he was doing this, he should probably know about the release of a new book called Killed Strangely: The Death of Rebecca Cornell.

The Cornells, you see, were direct ancestors of Fallon’s father. One of them, for instance, was Ezra Cornell, the founder of Cornell University. But Killed Strangely is about another, more sinister Cornell: Thomas Cornell, who killed his mother, Rebecca, and was hanged for it in 1673, the first case of matricide, Fallon says, recorded in the new American colonies.

Investigating further, Fallon discovered that the rabbit hole went even deeper. There were actually seven murders committed by those within his father’s family line. This line also included Lizzie Borden, his cousin, who was controversially acquitted of killing her father and stepmother with an axe in 1892.

Testing Enlightens the Fallons

After learning of his family’s bloody history, James Fallon decided to have brain imaging – PET scans and EEG’s – as well as genetic analyses carried out on himself and nine family members, including his parents, wife and children, to see if any had the markings of killers.

The results:

• All of the images of the family members’ brains were normal when analyzed for markers of potential violence…except for the images of one, Fallon’s own. His scan looked identical to those of the serial killers he had studied, with a malfunctioning limbic system lacking activity in the orbital cortex, anterior temporal lobes and areas connecting them.
• The entire family exhibited a typical mix of genes related to aggression, impulsivity and other relevant traits…except one member. Fallon himself not only had high-risk genes associated with violence, but he had far more of them than many psychopaths and killers. In fact, he says, he had almost all of them.

His family’s reaction to these results is quite interesting:

His son said that he always knew there was something “off” about his father and that, at times, he had feared him because he is a “hothead” with all the traits you’d expect in a serial killer. He said this makes more sense now that he knows that his father has the brain and genetics of a psychopath.

Fallon’s wife said the results were surprising, yet not surprising because he is, in a way, two people, with a funny, gregarious side mixed with a standoffish side.

James Fallon himself does admit to some macabre interests, a predilection for risk-taking and a superficial charm, which you might see in psychopaths and murderers. And he also admits he may sometimes be drawn to behavior that he knows is wrong but “still doesn’t care.”

The Third Ingredient

But, however imperfect, James Fallon is not violent or a killer. And this has enormous implications.

How is it that, despite having so many biological markers for violence, Fallon ended up a scholar rather than an aggressor or even a murderer?

Fallon has come to believe that, in addition to particular brain and genetic patterns, there is a third ingredient involved in the development of a violent psychopath. The environment, he explains, can help determine whether violence-related genes and certain brain processes, such as those involving mirror neurons, are triggered towards aggression. Specifically, he believes that abuse – especially severe early childhood sexual, physical or emotional abuse – is instrumental in this process. And he also believes that the precise timing of when various factors come into play is critically important in determining whether one becomes a psychopath and, if so, exactly what type of psychopathological behavior is exhibited.

As for why he himself is not a violent man, Dr. Fallon credits his upbringing in a highly nurturing environment, in which he was not only not abused, but was showered with wonderfully loving family support.

Some of Dr. James Fallon’s Appearances

Fallon has spoken on these topics in a number of forums, including:

• This television interview
• A TED talk entitled “Jim Fallon: Exploring the mind of a killer”Here, Fallon talks about his research and his story.

  He also gives a brief synopsis of a talk he did in Israel about his theory of transgenerational, sex-linked violence in perpetually conflicted world regions. His theory is that severe trauma before the onset of puberty triggers violent expression in those with violence-related genes such as, for example, the “Warrior” version of the MAOA gene. When this happens frequently in an area, the environment becomes increasingly threatening, so aggressive men, capable of physical protection and more likely to carry these genes, become more and more attractive to females. In consequence, violence-related genes become relatively highly concentrated in the population’s gene pool, sparking a vicious cycle.

  This theory is consistent with a similar, somewhat stunning, phenomenon that I discussed in my own writings on psychopathy.

• An episode of Reason TV called “Three Ingredients for Murder: Neuroscientist James Fallon on Psychopaths and Libertarians”Here, in addition to sharing his story, Fallon discusses the implications of work like his for our views of free will and responsibility, as well as for our legal system, especially in regards to psychopaths. He also discusses how our increasing ability to recognize each person’s unique makeup will challenge our capacity for creating standards in public policy and drive us toward individualized medicine. And he explains why he is a libertarian and how that may correlate with the function and/or lack of function in certain brain areas.

• A September 2011 episode of the BBC program Horizon entitled “Are You Good or Evil?”In these clips from the show, Fallon talks about his research on the brain scans of murderers, the tests carried out on him and his family and his discovery that his results showed the brain and genetic patterns seen in psychopathy.

  The first video also contains a quote that I found very powerful which serves to crystallize Fallon’s study of killers:

  It really indicated that there was a biological basis – a really hardcore brain basis – for this urge to kill.

  
  The second video includes the comments about his personality attributed earlier to his son and his wife.

• A segment called “Confessions of a Pro-Social Psychopath” produced by the World Science Festival in conjunction with The Moth, a non-profit that promotes storytelling.The title of this talk grabbed me because I had often wondered whether there could be “pro-social psychopaths,” but I had never heard the term used elsewhere. I also found this to be a nice overall telling of his story by Fallon.

Dr. Fallon also appeared on a November 18, 2009 episode of Criminal Minds, the CBS drama about FBI profilers. In the episode, which was based on his TED talk, he played himself giving a lecture about his theory of transgenerational violence in areas of conflict, which was mentioned earlier.

What Fallon May Tell Us About a Possible Future with Less Psychopaths and Killers

What are the implications of Fallon’s research and his story for society at large?

Well, there are some conditions for which we screen early in life. If we detect that a person has or is at risk for such a condition, we can then intervene in time to prevent or best manage it.

A good example is phenylketonuria (PKU). This is a genetic disorder in which an enzyme needed to properly metabolize a particular amino acid, phenylalanine, is rendered nonfunctional. As a result, a person with PKU who eats a normal diet can experience severe consequences including mental retardation.

Luckily, in most countries, newborns are screened for PKU. If it is detected, they can be put on a special diet in which phenylalanine is restricted and special supplements are provided. As a result, the person with PKU can live a normal, healthy life.

Fallon’s case raises the possibility that, as advocated by Adrian Raine, we may someday be able to screen children for a predisposition to psychopathy and, when they are identified as at-risk, intervene with special measures to prevent or best manage the development of violent or other dangerous propensities in at least some of them. Further research could be done to more specifically identify the types of measures that bring about the healthiest outcomes for such individuals and those around them. But it’s likely that these would include conscientious provision, throughout these youngsters’ upbringings, of the abundance of love and care for which Fallon credits his own nonviolent lifestyle.

In other words, we may someday see a future when all, or at least at-risk, families will be tested for the markers of violence just the way Fallon’s was so that those who do have the brains and genes we find in psychopaths can more often develop into, say, professors like James Fallon rather than killers like too many others – including some of those he has studied for a living and quite a few of his recent ancestors.