Just as I was making this realization, thanks to a number of resources on the topic, it seemed that much of the rest of the world was beginning to make the same realization. More and more stories related to the neuroscience of moral choice were coming out everywhere I looked. And dramas and books centering on psychopaths – perhaps the most fascinating examples of the stark difference between some humans and others in how they make moral choices – were attracting large audiences.

So I started this blog in order to help amplify this awakening to a new understanding about the factors underlying moral choice and, in turn, the types of events we refer to as “evil.”

Here on the blog, I’ve featured many stories that highlight the growing knowledge base at the intersection of neuroscience and morality. And today I read a quote that sums up well my feeling about this area of knowledge:

“It’s a field that’s waiting for a big revolution sometime soon.”

The quote is from Walter Sinnott-Armstrong, Professor in Practical Ethics at Duke University’s Department of Philosophy and Kenan Institute for Ethics. And it comes from an article by Health and Science reporter Elizabeth Landau called “How your brain makes moral judgments” posted on CNN.com today as part of its “Inside Your Brain” series.

Landau’s article features a nice selection of ideas and research studies in this area of the neuroscience of morality. It demonstrates, yet again, that we do seem to be on the cusp of the revolution in the field to which Sinnott-Armstrong refers – and which this blog exists to help, in some small measure, to bring about – and explores the implications of that revolution.

It covers a variety of studies, relating to which areas of the brain do what when people make moral decisions, by some of the top researchers in the field, such as Joshua Greene and Adrian Raine.

It specifically discusses what is different in the relevant brain circuits in psychopaths as compared with others, a topic covered extensively on this site, as well as in autism.

And in one of its more fascinating aspects, it discusses how interventions in brain processes can manipulate moral judgments. For instance, it talks about research by Rebecca Saxe, associate professor of cognitive neuroscience at MIT and associate member of the McGovern Institute for Brain Research, in which the application of transcranial magnetic stimulation (TMS) to a particular area of the brain led to a temporary shift in response when making moral judgments.

In the article, Sinnott-Armstrong is quoted regarding one of the most controversial aspects of ponerology, saying that he “thinks one day there could be treatments directly developed for the brain in extreme cases, such as criminal psychopaths.”

“‘It’s possible that if we understand the neural circuits that underlie psychopaths and their behavior, we can use medications and magnetic stimulation to change their behavior,’ he said.

Such techniques might not work as well as behavioral training programs, however, he said.”

The article also talks about how different brain areas may be involved in different kinds of moral judgments and whether there may be cross-cultural differences in moral judgment.

All in all, a very worthwhile article for those interested in these topics and yet another example of the increasing recognition of this crucial area of study.

So I looked into it.

It turned out that, on that day, Cooper had done a segment with James Fallon, the neuroscientist who, in the process of studying the genetics and brains of psychopathic killers, discovered that he himself, despite being a successful non-violent researcher, had many of the genetic and brain markers associated with psychopathy.

I wrote a very detailed post about Fallon and his fascinating story last year called “Neuroscientist James Fallon’s Work & Life Shed Light on How Psychopathic Killers are Made…and Perhaps Prevented.” So I won’t cover that in any more detail here.

But Fallon has recently released a book about his story called The Psychopath Inside: A Neuroscientist’s Personal Journey into the Dark Side of the Brain. And, in the wake of the book’s release, he has been showing up more frequently in the media, sharing his insights about psychopathy, its impact in the world, and what his story tells us about the possibility of reducing the number of psychopaths that develop, which is wonderful.

The interview with Anderson Cooper is below and, even though this clip is only five minutes long, it could be five of the most important minutes I’ve ever seen on television.

Early in the interview, Fallon:

• Shares a bit about his story
• Talks about the psychopathic traits that can be recognized by looking at brain scans
• Explains the difference between the “cognitive empathy” that he and psychopaths have and “emotional empathy,” which they tend to lack

The upshot of Fallon’s story is that, despite having the genetic and biological markers for psychopathic traits, he did not become a full blown psychopath. In fact, he became a very productive, contributing member of society. He believes the reason is that he had a very loving upbringing, which counteracted his destructive biological predispositions. And he believes that such an upbringing can have the same beneficial impact on others with similar biological predispositions.

As Fallon tells Cooper:

“I thought everything was driven by genetics, biology. And I didn’t think nurture had anything to do with it. Once I realized, because of the genes I have, that if you’re brought up in a very nurturing environment, you can offset the biology.”

I agree that Fallon’s case offers us hope that, at least in a subset of cases, people with biological propensities for psychopathic traits can be prevented from becoming full-blown psychopaths. However, I still think a lot more research is needed to determine how generalizable his case is. Is Fallon representative of all or most people with these markers or is he in some way a rare or special case?

Contrast Fallon’s statement that a caring upbringing can offset biological predispositions for psychopathic traits with this quote from Evil Genes: Why Rome Fell, Hitler Rose, Enron Failed, and My Sister Stole My Mother’s Boyfriend by Barbara Oakley:

“Oddly enough, one study has shown that murderers who have a normal family upbringing have even lower function in their right orbitofrontal cortical areas than murderers who were abused during childhood. Perhaps murderers without a psychosocial ‘push’ toward violence require a greater neurobiological ‘push.’ In other words, children with less severe neurological problems may be helped by having a normal upbringing – but children with more severe neurological difficulties may not be.”

The study Oakley cites for this claim in the book’s footnotes is:

Adrian Raine et al., “Reduced Prefrontal and Increased Subcortical Brain Functioning Assessed Using Positron Emission Tomography in Predatory and Affective Murderers,” Behavioral Sciences and the Law 16 (1998): 319-32.

I would like to see work to determine how Fallon’s claims and those of Raine’s study, which Oakley cites, can be reconciled.

The entire five minute clip of Cooper’s interview with Fallon is important. But, its last two minutes, from 3:13 on, take that to an even higher level, consisting of about as significant an exchange as I’ve ever seen aired.

Anderson Cooper basically admits to being convinced of the central point that many advocates of ponerology, from Andrew Lobaczewski on, have been trying to bring to public attention for decades now – that the influence of psychopathy and psychopathic traits in our world, including in circles of power – and specifically in the very highest circles of political power – is much greater than most people recognize.

Cooper says:

“I find this whole topic of psychopaths really interesting because I’m convinced there’s a lot more people out there who are psychopaths than we realize and particularly successful people, accomplished people, people on TV, people in the political sphere. I’m convinced there are tons of psychopaths.”

Fallon responds:

“If you look at, there was just a study done, a scientific study of all our presidents. And all the biographers answered all these questions about them and it was on a scale of psychopathy. And on the scale of psychopathy, in sort of the one part of psychopathy, not the criminality part but the other part which is a big part of psychopathy, the ones who scored very high were Theodore Roosevelt, JFK, FDR, Bill Clinton very high. The ones who had no psychopathy at all in this were people like Jimmy Carter, Gerald Ford.

And when you look at the association of those psychopathic traits with leadership, it’s like we want these people, right, because they do things that are…they take chances, they lie at the right time. You know, FDR was lying all the time but he saved us so it was OK. So if you look at people that we choose to be leaders I think a lot of them have these traits and they’re part of leadership skills.”

Cooper then adds:

“I also think what it takes to propel somebody into the public sphere or propel somebody to success, I mean, it’s not, they are not normal impulses, I think and I think a lot of them are psychopathic impulses.”

Fallon responds:

“If you have that grand vision, cause psychopaths will have a grand vision – not all of them, some are just lousy rats – but people have that grandiose, narcissistic need and they’ve got something to prove and they’ve got something they say I’m gonna save the world. That’s part of it. Doesn’t make you psychopathic but it’s one of the traits that fits into this puzzle of psychopathy.”

Anderson Cooper is one high-profile journalist that seems to have realized the tremendous importance of ponerologic topics. Not long ago, he did a segment about Ariel Castro, the man who abducted three girls and held them captive for nearly ten years, in which the topic of psychopathy was front and center. Kudos to Cooper for recognizing how crucial it is that we educate the public on this subject and for courageously covering it on his show.

And the huge traffic surge that I saw as people looked for information in the wake of his interview with James Fallon?

That shows how much interest there is among the public about this topic. And it’s very heartening to see that interest increasingly being met not just by sensationalized fiction or news focused on titillating crimes, but by objective science disseminated by competent researchers and clinicians.

As for the psychopath test:

Well, after the interview with Fallon, not shown in the clip in this post, Cooper said:

“As I said, I find this just amazing. If you’re curious about where you fall on that scale of psychopathy, you can actually take a test to find out. We’ve posted it on our web site AC360.com. It just takes a couple of minutes. I’ve taken it. Pretty much everyone on our staff has taken it and let’s say the results are very, very interesting.”

The link he references on the AC360 blog is here.

And, from that page, it links to the quizzes page associated with Channel 4’s episode “Psychopath Night”, which features tests devised by Kevin Dutton, author of The Wisdom of Psychopaths.

So I’ve been grateful to them for connecting me to those issues and feelings through the song. But then, last night, they connected me to them in another way that is extremely relevant to ponerology.

Pearl Jam performed on “Late Night with Jimmy Fallon” last night. Well, technically, their taped performance from an earlier time was played. In fact, they played a live show in Hartford, Connecticut last night. So after watching the airing of their performance on Fallon’s show, I was just looking around on Twitter to see what people were saying about it.

Instead, I ran into this tweet from the band regarding the show in Hartford:

“Come Back” was dedicated to Avielle Richman who would’ve turned 7 on 10/17. @AvieFoundation @sandyhook #PJHartford pic.twitter.com/WCvMqlkHXt

— Pearl Jam (@PearlJam) October 26, 2013

I was instantly hit with a mix of heartbreak for the obvious tragedy the tweet alluded to and curiosity about what the “Avie Foundation” was all about.

So I clicked through to their Twitter account.

The description reads:

“The Avielle Foundation – A non-profit foundation dedicated to preventing violence through brain health research and fostering community engagement and education.”

This grabbed me immediately. In the wake of the tragic loss of this little girl and many other children at Sandy Hook Elementary School, this group is advocating for the importance of understanding the link between the biology of the brain and violence. The relevance to ponerology could not be clearer.

I then clicked through to their website.

It tells the story of Avielle’s life.

It describes the organization’s mission.

And then the motivation behind the Foundation was revealed even more when I looked at the page about its founders.

The leading founders listed are Jeremy Richman, Ph.D., trained in pharmacology and toxicology and having worked in, among many other areas, neuroscience, and Jennifer Hensel, M.S., a multi-disciplinary scientist. They are also Avielle’s parents.

As a scientific discipline, ponerology encourages us to consider and respond to events often labeled as “evil” by applying the methods and tools of science. One of the victims of the Sandy Hook tragedy, Avielle Richman, was the child of two parents who are scientists. And in response, they have created a foundation through which to apply their expertise in science toward preventing violence.

The organization’s objectives revolve around addressing the causes of violence through a focus on what the organization terms “brain health.” They have very consciously chosen this term. As they explain:

“We want to start using this term, brain health, because mental health is intangible – it comes with some degree of trepidation and stigma. But we know there are real, physical manifestations within the brain that can be imaged, measured, quantified, and understood – We can work with that, and then, we can fix it.”

Specifically, their two objectives are:

1. “Understand the Underpinnings in the Brain That Lead to Malevolent Behaviors”
2. “Brain Health Community”

These are goals at the very heart of what ponerology and my interest in it are all about.

In the wake of the events at Sandy Hook and similar events elsewhere, people have channeled their anger and despair into certain causes usually focused on gun control or generally improving mental health awareness and treatment. But far too few have focused on something even more precise and central to the genesis of violence – the very biology of the violent brain.

Progress in the objectives of the Avielle Foundation could do so much to really get at the root of why tragedies like the one in Newtown continue to occur and how to reduce their likelihood. And I cannot think of a more fitting and meaningful way for these parents to honor their daughter’s memory than in working toward these goals.

I then wondered if those at the organization were aware of the many other researchers who have done such great work on topics related to their mission, a number of whom have been featured on this site. That question was answered when I looked at their impressive Science Advisory Board, which includes some of the most outstanding researchers on ponerology-related topics, including:

• Dr. James Blair, whose name is ubiquitous whenever I look at the research on the biology of aggression and malice, and who is mentioned in this post about a researcher that did post-doctoral work with him.
• Dr. Adrian Raine, author of The Psychopathology of Crime: Criminal Behavior as a Clinical Disorder and The Anatomy of Violence: The Biological Roots of Crime, whose fascinating work and ideas have been discussed in several posts on this site.

Sometimes in life, a perfect storm happens. Sometimes it is a storm we wish never did happen. But out of that perfect storm can come something special. It is remarkable that one of Sandy Hook’s victims happened to have parents like this with just the background to be able to turn this horrible event into a movement with real potential to focus people on something so crucial and so often neglected – study of the biological underpinnings of violence and how we can foster healthier, less violent brains in our world.

The fact that Pearl Jam, an extremely socially conscious band – and one whose career was, in many ways, launched by a song and video about violence in school – got involved and happened to play in Hartford, so close to Newtown, the night I was looking at tweets about them, and that I then became aware of all of this through them is just another aspect of that perfect storm. Perhaps, with all this talk of storms, it’s fitting that the band’s new album, which started me down the path that led me to learn about the Avielle Foundation, is called “Lightning Bolt.”

Thank you to Pearl Jam for helping to promote this incredibly important subject matter by bringing attention to this great organization. Thank you to the scientists getting involved in this organization. And thank you most of all to Avielle’s parents for allowing their loss and grief to be catalysts for the very sort of effort so badly needed.

This is the precise type of organization that this world desperately needs.

The other day, after playing “Sirens” over and over, I went to share the song with my father. After he heard it, he saw a link to Pearl Jam’s famous video for “Jeremy,” which he hadn’t seen before. As he played that video – directed, in yet another example of a perfect storm element, by Mark Pellington, who also signed on to direct the pilot episode of a television show based on Raine’s Anatomy of Violence - I mentioned how timely it was since just that day there was another school shooting, this time in Sparks, Nevada. He hadn’t heard about the incident. And I mentioned that, sadly, we’ve gotten to the point where a school shooting can happen and elude our radar because we are becoming so numb to it.

The Avielle Foundation is doing the kind of work that we need to really understand how to change this situation.

Learn how you can help them in their mission by donating or volunteering to get involved with the Avielle Foundation here.

Our last post focused on Raine’s essay “The Criminal Mind,” featured in the April 27, 2013 Wall Street Journal, in which he discussed how advances in our understanding of the genetic, neurological and environmental bases of violence are influencing our view of and approach to crime.

Now another large media outlet, CNN, has run not one, but two segments featuring Raine’s work.

In a segment entitled “The Anatomy of Violence: A look inside the minds of killers,” CNN Chief Medical Correspondent Dr. Sanjay Gupta talked to Raine and discussed his work’s possible relevance in understanding why the Boston Marathon bombings occurred.

The segment opens with footage of the bombings, over which Gupta says:

“In the wake of tragedy come the inevitable questions. What makes a killer? Is there a switch that turns on a rampage? And why? Why would someone do this?”

Adrian Raine then appears on the screen and says that to simply label a person that commits such acts “evil” is “13th-century thinking.” Gupta introduces Raine, explaining that Raine believes there are “biological explanations for violence” and Raine then explains why he believes that brain dysfunction may partly explain the Boston Marathon bombings.

One interesting condition that Raine mentions that he found relevant, given that the older of the two brothers charged with the bombings, Tamerlan Tsarnaev, was a very skilled boxer, is a recognized brain abnormality called Cavum Septum Pellucidum. Raine says that this condition, in which a maldeveloped limbic system fails to normally put pressure on and thus fuse the leaflets of the Septum Pellucidum, predisposes to a psychopathic personality marked by fearlessness and the ability to commit remorseless violence. For whatever it is worth, he says it has also been found in boxers.

In fact, in reading Wikipedia’s page about Cavum Septum Pellucidum, I became aware that perhaps the most famous fictional boxer of all time, Rocky Balboa, was specifically told in Rocky V that he had this very condition.

I could only find video of the scene in which Rocky receives this diagnosis online in Italian. And the translation has “pellucidum” apparently incorrectly transformed into “pelliculum,” which may be why the poster put a question mark at the end of the video’s title of “Cavum Septum Pelliculum?” You can see an English translation here. But here is the clip.

Gupta then shows us, using imagery from a psychopath’s brain, the smaller amygdalae found in psychopaths in Raine’s research, which also contribute to the fearlessness and disinhibition that could enable one to commit harmful acts like the Boston bombings.

Gupta also discussed the possible link between Raine’s work and the Boston Marathon bombings in another segment on the CNN program The Lead with Jake Tapper.

During the segment, which begins with the lower third title again saying “The Anatomy of Violence: A look inside the minds of killers,” host Tapper says, in reference to those bombings, that we are trying to “understand this unmitigated evil.” In that spirit, he asks Gupta about the bombers, Dzhokar and Tamerlan Tsarnaev themselves, as well as about the three men later arrested for having attempted to help Dzhokar cover up his involvement. Gupta mentions having spoken to Adrian Raine about this topic and says it may be relevant to understand that Dzhokar and the three arrested later, all being just 19 years old, may have had a combination of fully developed and fueled emotional brain centers along with not-yet-fully-developed judgment centers in their frontal lobes.

The title in the lower third then changes to “The Mind of a Terror Suspect: Could brain chemistry have played role in bombings?”

Tapper raises the issue of whether defense attorneys will use our increased insight into the genetic and neurological underpinnings of harmful behavior to argue that their clients’ actions should be excused. Gupta calls our advancing understanding of the biological roots of crime and violence “an emerging science” and then offers two examples that really highlight the difficulty of assigning appropriate levels of blame to those that commit harmful acts while suffering from certain biological conditions.

• First, Gupta mentions that Fetal Alcohol Syndrome, in which a mother’s drinking during pregnancy harms the developing fetus’ brain, leads that baby in later life to have a much higher likelihood of committing crimes and a nineteen times greater chance than otherwise of ending up in prison.
• Gupta also mentions how a brain tumor can drastically change an otherwise normally-functioning person’s behavior.

This is one of the first times I have seen ponerologic material discussed so explicitly on CNN. However, it isn’t the first. For instance:

• In the wake of the Newtown school shootings, I saw Erin Burnett interview Dr. James Fallon about the biological markers of psychopathy and whether he expected them to be discovered post-mortem in shooter Adam Lanza.

• I also saw a recent segment in which anchor Don Lemon intereviewed criminal profiler Jim Clemente and forensic psychiatrist Helen Morrison about the prevalence of sociopathy. (I tried to find video of this latter segment to share on this site but it seems it was never posted online. However, the transcript of the segment can be found about 1/4 of the way down the page of this transcript of Lemon’s entire show that night.)

But it was really nice to see Sanjay Gupta, who I believe is deservedly highly regarded as a physician, scientist and journalist, covering this topic from a professional and medical perspective. This is the type of coverage I would love to see more of on CNN and similar networks. And I’m glad that I have seen a lot more of it in the past few months than I can remember ever seeing before.

Today’s Wall Street Journal features a sizeable piece by Raine as its “Saturday Essay.”

The title of the essay is “The Criminal Mind” and underneath the title it says “Advances in genetics and neuroscience are revolutionizing our understanding of violent behavior—as well as ideas about how to prevent and punish crime.”

It doesn’t get much more relevant to ponerology than that. And it’s heartening to see Raine given a platform to share his extremely important and provocative ideas in The Wall Street Journal just in advance of the release of his book The Anatomy of Violence: The Biological Roots of Crime.

Raine’s essay touches on:

• The history of criminology as a science and its sometimes unfortunate devolution into pseudoscience
• The rise of neurocriminology
• The roles of genetics, environmental and developmental factors and brain structure and function in the emergence of aggression and antisocial behavior
• The political and social implications of a focus on biological bases for crime
• Recommendations for legal policies that account for our growing ponerologic understanding by both assigning appropriate levels of responsibility to offenders and optimally protecting the rest of society from the threats they pose
• Measures – including some relatively non-invasive ones – that can help significantly reduce the likelihood of harmful behavior in children that display signs of severe aggression

The article is accompanied by the video below. In it, Raine explains the relationship between diminished prefrontal cortex activity and violence, how such prefrontal dysfunction originates and possible treatments for such conditions, as well as how those with normal prefrontal activity but undersized amygdalae can also commit violence in a more planned and calculating fashion.

Raine also offers his opinion in the video about the Tsarnaev brothers who bombed the Boston Marathon.

Most who work in the fields that study aspects of this question take the view that the answer involves some combination of the two.

But this still leaves us with another question. In what proportion do each of these factors contribute in which people?

One remarkable case offers some fascinating insight on the subject.

Dr. James Fallon

James Fallon, Ph.D. is a highly decorated neuroscientist and Professor Emeritus of Anatomy and Neurobiology at University of California, Irvine. Dr. Fallon has several areas of expertise. One is adult stem cells. Another is psychiatry. Specifically, he is interested in the relationships between brain imaging (he has served as Director of UC Irvine’s Human Brain Imaging Center), genetics and various psychiatric conditions, including schizophrenia, depression and addictions.

An Extraordinary Experiment

Aware of his specialties, for many years, Fallon’s colleagues have sent him brain images they wished to have him analyze.

At one point this interchange took the form of an experiment.

Colleagues sent him 70 MRI scans of brains belonging to people ranging from healthy to mentally ill. Included in the batch were scans of brains belonging to killers, including some notorious ones. But Fallon had no idea which scanned brain belonged to whom.

Nonetheless, he was able to identify differences in five of the scans so dramatic that he could recognize them as the markers of psychopathy. And it turned out that he was correct. The five scans on which he zeroed in actually were those from the brains of psychopathic serial killers.

Signs of the Psychopath’s Brain

How could Fallon distinguish the serial killers’ brain scans from the others? He says that all five had some tell-tale signs:

• A lack of activity in the orbital cortex, the brain area just above the eyes, which he says is in the circuit coding for ethics, conscience and impulse control
• A lack of activity in the anterior part of the temporal cortex, where we find the amygdala, a structure deeply involved in processing emotion
• Underfunctioning in the narrow strip of limbic cortices that connect the orbital cortex with the amygdala, namely:
  • The cingulate cortex, which codes for social cues
  • The hippocampal area, which, along with the amygdala, codes for emotional memories
  • The insula, which processes empathy and “gut feelings”

This makes sense. These areas are considered part of the limbic system, the brain complex primarily responsible for our emotional lives. When these areas are underactive or inactive, a person might feel driven – like many killers – to compensate by repeatedly pursuing extreme activities simply to feel satisfied and alive.

Violence-Related Genes

In addition to his study of killers’ brains, Fallon has also studied the genetics of aggression and violence.

Psychological traits are affected by multiple genes. And Fallon says that perhaps a dozen have been identified as high-risk, violence-related genes. These include genes affecting dopamine and norepinephrine neurotransmission and androgen (testosterone) receptors.

The most well-known of these violence-related genes is a particular version of the Monoamine Oxidase A (MAOA) gene. Because it was the first such gene discovered, it was labeled, and has become popularly known as, “the Warrior Gene,” although Fallon stresses that this nickname can be misleading since all of the various genes associated with violence and aggression could be considered, in a sense, warrior genes.

Most humans have an MAOA gene and it helps regulate serotonin, a neurotransmitter that Fallon says helps relax and calm us. But those with the “Warrior Gene” form of it receive too much serotonin during development in utero, which desensitizes the brain to its effects. That means that later in life, when serotonin would otherwise inhibit behavior, it is unable to do so, resulting in impulsivity and violence.

The MAOA gene is on the X chromosome. This has important implications for how its effects express themselves in males vs. females. Girls get an X chromosome from both their mother and father, so even if one parent passes along the “Warrior Gene” variant, they are likely to get a normally functional MAOA variant from the other parent that offsets its potentially dangerous consequences. But boys get only one X chromosome – the one passed down from their mother. If that X chromosome has the “Warrior” version of the MAOA gene, that will be the only version of it that the boy receives.

This means that violence related to the MAOA “Warrior Gene” is usually passed genetically from mother to son. Fallon believes it also explains why boys and men are much more likely to be very aggressive or psychopathic killers.

Moreover, Fallon says that the reduced empathy seen in psychopathy may be associated with the influence of low acting genes related to the hormones oxytocin and vasopressin.

Can Biology Alone Create a Psychopath?

So, putting this together, Fallon recognized patterns in both the brains and genetics of psychopathic killers.

1. Loss of function in the orbital cortex, anterior temporal lobes and the strip of limbic cortices connecting the two
2. Having one or more of several high-risk, violence-related genes (like the so-called “Warrior Gene”)

But a crucial question remained. Are these biological markers alone enough to create a psychopath?

Fallon suspected not. But little did he know that he would receive some validation for this suspicion from so close to home.

A Shocking Fallon Family Pattern is Revealed

Based on his work, Fallon was giving many presentations about psychopathic killers. His mother said that, since he was doing this, he should probably know about the release of a new book called Killed Strangely: The Death of Rebecca Cornell.

The Cornells, you see, were direct ancestors of Fallon’s father. One of them, for instance, was Ezra Cornell, the founder of Cornell University. But Killed Strangely is about another, more sinister Cornell: Thomas Cornell, who killed his mother, Rebecca, and was hanged for it in 1673, the first case of matricide, Fallon says, recorded in the new American colonies.

Investigating further, Fallon discovered that the rabbit hole went even deeper. There were actually seven murders committed by those within his father’s family line. This line also included Lizzie Borden, his cousin, who was controversially acquitted of killing her father and stepmother with an axe in 1892.

Testing Enlightens the Fallons

After learning of his family’s bloody history, James Fallon decided to have brain imaging – PET scans and EEG’s – as well as genetic analyses carried out on himself and nine family members, including his parents, wife and children, to see if any had the markings of killers.

The results:

• All of the images of the family members’ brains were normal when analyzed for markers of potential violence…except for the images of one, Fallon’s own. His scan looked identical to those of the serial killers he had studied, with a malfunctioning limbic system lacking activity in the orbital cortex, anterior temporal lobes and areas connecting them.
• The entire family exhibited a typical mix of genes related to aggression, impulsivity and other relevant traits…except one member. Fallon himself not only had high-risk genes associated with violence, but he had far more of them than many psychopaths and killers. In fact, he says, he had almost all of them.

His family’s reaction to these results is quite interesting:

His son said that he always knew there was something “off” about his father and that, at times, he had feared him because he is a “hothead” with all the traits you’d expect in a serial killer. He said this makes more sense now that he knows that his father has the brain and genetics of a psychopath.

Fallon’s wife said the results were surprising, yet not surprising because he is, in a way, two people, with a funny, gregarious side mixed with a standoffish side.

James Fallon himself does admit to some macabre interests, a predilection for risk-taking and a superficial charm, which you might see in psychopaths and murderers. And he also admits he may sometimes be drawn to behavior that he knows is wrong but “still doesn’t care.”

The Third Ingredient

But, however imperfect, James Fallon is not violent or a killer. And this has enormous implications.

How is it that, despite having so many biological markers for violence, Fallon ended up a scholar rather than an aggressor or even a murderer?

Fallon has come to believe that, in addition to particular brain and genetic patterns, there is a third ingredient involved in the development of a violent psychopath. The environment, he explains, can help determine whether violence-related genes and certain brain processes, such as those involving mirror neurons, are triggered towards aggression. Specifically, he believes that abuse – especially severe early childhood sexual, physical or emotional abuse – is instrumental in this process. And he also believes that the precise timing of when various factors come into play is critically important in determining whether one becomes a psychopath and, if so, exactly what type of psychopathological behavior is exhibited.

As for why he himself is not a violent man, Dr. Fallon credits his upbringing in a highly nurturing environment, in which he was not only not abused, but was showered with wonderfully loving family support.

Some of Dr. James Fallon’s Appearances

Fallon has spoken on these topics in a number of forums, including:

• This television interview
• A TED talk entitled “Jim Fallon: Exploring the mind of a killer”Here, Fallon talks about his research and his story.

  He also gives a brief synopsis of a talk he did in Israel about his theory of transgenerational, sex-linked violence in perpetually conflicted world regions. His theory is that severe trauma before the onset of puberty triggers violent expression in those with violence-related genes such as, for example, the “Warrior” version of the MAOA gene. When this happens frequently in an area, the environment becomes increasingly threatening, so aggressive men, capable of physical protection and more likely to carry these genes, become more and more attractive to females. In consequence, violence-related genes become relatively highly concentrated in the population’s gene pool, sparking a vicious cycle.

  This theory is consistent with a similar, somewhat stunning, phenomenon that I discussed in my own writings on psychopathy.

• An episode of Reason TV called “Three Ingredients for Murder: Neuroscientist James Fallon on Psychopaths and Libertarians”Here, in addition to sharing his story, Fallon discusses the implications of work like his for our views of free will and responsibility, as well as for our legal system, especially in regards to psychopaths. He also discusses how our increasing ability to recognize each person’s unique makeup will challenge our capacity for creating standards in public policy and drive us toward individualized medicine. And he explains why he is a libertarian and how that may correlate with the function and/or lack of function in certain brain areas.

• A September 2011 episode of the BBC program Horizon entitled “Are You Good or Evil?”In these clips from the show, Fallon talks about his research on the brain scans of murderers, the tests carried out on him and his family and his discovery that his results showed the brain and genetic patterns seen in psychopathy.

  The first video also contains a quote that I found very powerful which serves to crystallize Fallon’s study of killers:

  It really indicated that there was a biological basis – a really hardcore brain basis – for this urge to kill.

  
  The second video includes the comments about his personality attributed earlier to his son and his wife.

• A segment called “Confessions of a Pro-Social Psychopath” produced by the World Science Festival in conjunction with The Moth, a non-profit that promotes storytelling.The title of this talk grabbed me because I had often wondered whether there could be “pro-social psychopaths,” but I had never heard the term used elsewhere. I also found this to be a nice overall telling of his story by Fallon.

Dr. Fallon also appeared on a November 18, 2009 episode of Criminal Minds, the CBS drama about FBI profilers. In the episode, which was based on his TED talk, he played himself giving a lecture about his theory of transgenerational violence in areas of conflict, which was mentioned earlier.

What Fallon May Tell Us About a Possible Future with Less Psychopaths and Killers

What are the implications of Fallon’s research and his story for society at large?

Well, there are some conditions for which we screen early in life. If we detect that a person has or is at risk for such a condition, we can then intervene in time to prevent or best manage it.

A good example is phenylketonuria (PKU). This is a genetic disorder in which an enzyme needed to properly metabolize a particular amino acid, phenylalanine, is rendered nonfunctional. As a result, a person with PKU who eats a normal diet can experience severe consequences including mental retardation.

Luckily, in most countries, newborns are screened for PKU. If it is detected, they can be put on a special diet in which phenylalanine is restricted and special supplements are provided. As a result, the person with PKU can live a normal, healthy life.

Fallon’s case raises the possibility that, as advocated by Adrian Raine, we may someday be able to screen children for a predisposition to psychopathy and, when they are identified as at-risk, intervene with special measures to prevent or best manage the development of violent or other dangerous propensities in at least some of them. Further research could be done to more specifically identify the types of measures that bring about the healthiest outcomes for such individuals and those around them. But it’s likely that these would include conscientious provision, throughout these youngsters’ upbringings, of the abundance of love and care for which Fallon credits his own nonviolent lifestyle.

In other words, we may someday see a future when all, or at least at-risk, families will be tested for the markers of violence just the way Fallon’s was so that those who do have the brains and genes we find in psychopaths can more often develop into, say, professors like James Fallon rather than killers like too many others – including some of those he has studied for a living and quite a few of his recent ancestors.

It reads “Kids Can Be Psychopathic, Too.”

The article focuses heavily on – and introduced me to – the work of Adrian Raine, a professor of criminology, psychiatry and psychology on the faculty of the University of Pennsylvania’s Jerry Lee Center of Criminology.

Raine is the author of the textbook The Psychopathology of Crime: Criminal Behavior as a Clinical Disorder. And, as described in the article, he holds two highly controversial and enormously challenging beliefs:

• He believes that we will soon be able to use medical tests to determine whether a child is predisposed to grow up to be a psychopath.
• And he also believes that, once we are able to do that, we should screen children for traits linked to psychopathy.

The Philly Mag article itself is well worth the read, as it offers a fascinating look at:

• A brief historical overview of criminology and the nature vs. nature debate
• Structural and functional differences in the brains of psychopaths as opposed to those of non-psychopaths
• How psychopaths are responsible for crime at levels vastly disproportionate to their numbers
• What separates successful from unsuccessful psychopaths
• Genes influencing brain structure that are associated with antisocial and aggressive behavior
• Raine’s research showing certain differences among young children, which he believes are innate and biologically-based, that help predict which ones will exhibit future aggression and criminality
• Why, when it comes to the “chicken or egg” question regarding biological differences and psychopathy, Raine falls on the “biology as cause” side of the debate
• Why many resist biological explanations of “bad” behavior
• Interventions that might help children predisposed to criminal behavior
• Responses from others to Raine’s suggestion that we screen children for psychopathy-linked traits

I highly recommend taking the time to check it out.

But I bring up that article here in order to preface a new and exciting development regarding Adrian Raine that has come to my attention.

One other phenomenon that Hingston’s piece touches on is the recent explosion of media – including films (such as We Need to Talk About Kevin) and television shows (such as Dexter) – dealing with the subject of psychopathy. The article credits Raine’s investigations into the brains of criminals – neurocriminology research – for providing the platform for this explosion. If attributing this credit to Raine is appropriate then it is only fitting that his work will now serve as the basis for a television show in an even more direct manner.

Raine has a new book schedule for release on April 30, 2013 entitled The Anatomy of Violence: The Biological Roots of Crime.

According to TV Guide, the highly successful producers of the show Homeland, Howard Gordon and Alex Gansa, sold a show based on that book to CBS and will write and executive produce a pilot episode.

Deadline.com reports that a third Homeland producer, Alex Cary, has also joined the team.

Another Deadline.com article reports that the pilot will be directed by Mark Pellington (perhaps best known for his work on the powerful video for the Pearl Jam song “Jeremy”) and that David Harewood, who appears in the cast of Homeland (and whose brief but theatrical appearance as the Prince of Morocco in Michael Radford’s film version of The Merchant of Venice I found memorably amusing), is the first actor cast for it. It describes the show as featuring “Raines, a criminal psychologist with an expertise in sociopaths”

It should be very interesting to see how the pilot is received and if the show can go on to further promote Adrian Raine’s deeply important work and provide even more public awareness and education regarding research into the biological roots of aggression and harm and other ponerologic themes.