Several researchers, such as Adrian Raine, have done work studying the brains and neurological responses of children who exhibit traits often found in psychopaths and today we look at another such researcher.

Abigail Marsh is an assistant professor of psychology at Georgetown University who directs the school’s Laboratory on Social and Affective Neuroscience. This lab uses cognitive neuroscience methods to explore, among other things, the roots of empathy.

Marsh’s path to interest in this topic is, as is true for many of us who have been drawn to it, a compelling one. As she explains in her profile on her lab’s website, when she was 20 years old, she was in an accident, after which a stranger saved her life. And, as she explains in another interview, a few years later, a different stranger punched her in the face, breaking her nose.

Events like these led her to wonder why some people help others and some harm others. Her quest for answers led her to earn a Ph.D. in Social Psychology from Harvard and to do post-doctoral work with James Blair, another leader in the field who has done great work on these subjects.

As described by Georgetown University News, Marsh’s latest research – which also involved the National Institutes of Health, the Center for Disease Control and Prevention and several other researchers including Blair – showed that “young people with conduct problems and psychopathic traits such as callousness and remorselessness show less activity in the regions of the brain associated with empathy.”

Specifically, functional magnetic resonance imaging (fMRI) was used to measure brain activity as two different groups of adolescents looked at photographs of other people experiencing pain-inducing injuries while imagining either that the body in the photo was their own or someone else’s.

The first group consisted of adolescents with both:

• Psychopathic Traits
• Conduct Disorder or Oppositional Defiant Disorder

The second group was a control group of youngsters of matched age, gender and intelligence.

The study found that:

• As the injuries depicted became more painful, the youngsters with psychopathic traits showed reduced activity in the rostral anterior cingulate cortex, ventral striatum (putamen), and amygdala, all of which are brain regions associated with the experience of empathic pain.
• Amygdala activity was especially reduced when perceiving the injury as happening to another person rather than oneself.
• Youngsters whose scores on the PCL:YV (the Youth Version of the Hare Psychopathy Checklist) were higher, indicating more severe psychopathic traits, showed less activity in the amygdala and rostral anterior cingulate cortex, specifically.

The researchers also discovered that, in the group with psychopathic traits, lower responsiveness was predictive of psychopathic symptom severity.

The formal title of the study is “Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits.” It is published in the March 12, 2013 issue of the Journal of Child Psychology and Psychiatry.

In the Georgetown University News piece, Abigail Marsh says that, in her future work, she hopes to help tease out even more fully the various types of different mechanisms underlying helpful and harmful behavior. She explains, “I will continue to use brain imaging, genetic and behavioral research paradigms in healthy adults and adolescents as well as adolescents with conduct problems to try to understand the origins of empathy, aggression, and altruism.” Such important goals position her work squarely in the realm of ponerology.

Our last post focused on Raine’s essay “The Criminal Mind,” featured in the April 27, 2013 Wall Street Journal, in which he discussed how advances in our understanding of the genetic, neurological and environmental bases of violence are influencing our view of and approach to crime.

Now another large media outlet, CNN, has run not one, but two segments featuring Raine’s work.

In a segment entitled “The Anatomy of Violence: A look inside the minds of killers,” CNN Chief Medical Correspondent Dr. Sanjay Gupta talked to Raine and discussed his work’s possible relevance in understanding why the Boston Marathon bombings occurred.

The segment opens with footage of the bombings, over which Gupta says:

“In the wake of tragedy come the inevitable questions. What makes a killer? Is there a switch that turns on a rampage? And why? Why would someone do this?”

Adrian Raine then appears on the screen and says that to simply label a person that commits such acts “evil” is “13th-century thinking.” Gupta introduces Raine, explaining that Raine believes there are “biological explanations for violence” and Raine then explains why he believes that brain dysfunction may partly explain the Boston Marathon bombings.

One interesting condition that Raine mentions that he found relevant, given that the older of the two brothers charged with the bombings, Tamerlan Tsarnaev, was a very skilled boxer, is a recognized brain abnormality called Cavum Septum Pellucidum. Raine says that this condition, in which a maldeveloped limbic system fails to normally put pressure on and thus fuse the leaflets of the Septum Pellucidum, predisposes to a psychopathic personality marked by fearlessness and the ability to commit remorseless violence. For whatever it is worth, he says it has also been found in boxers.

In fact, in reading Wikipedia’s page about Cavum Septum Pellucidum, I became aware that perhaps the most famous fictional boxer of all time, Rocky Balboa, was specifically told in Rocky V that he had this very condition.

I could only find video of the scene in which Rocky receives this diagnosis online in Italian. And the translation has “pellucidum” apparently incorrectly transformed into “pelliculum,” which may be why the poster put a question mark at the end of the video’s title of “Cavum Septum Pelliculum?” You can see an English translation here. But here is the clip.

Gupta then shows us, using imagery from a psychopath’s brain, the smaller amygdalae found in psychopaths in Raine’s research, which also contribute to the fearlessness and disinhibition that could enable one to commit harmful acts like the Boston bombings.

Gupta also discussed the possible link between Raine’s work and the Boston Marathon bombings in another segment on the CNN program The Lead with Jake Tapper.

During the segment, which begins with the lower third title again saying “The Anatomy of Violence: A look inside the minds of killers,” host Tapper says, in reference to those bombings, that we are trying to “understand this unmitigated evil.” In that spirit, he asks Gupta about the bombers, Dzhokar and Tamerlan Tsarnaev themselves, as well as about the three men later arrested for having attempted to help Dzhokar cover up his involvement. Gupta mentions having spoken to Adrian Raine about this topic and says it may be relevant to understand that Dzhokar and the three arrested later, all being just 19 years old, may have had a combination of fully developed and fueled emotional brain centers along with not-yet-fully-developed judgment centers in their frontal lobes.

The title in the lower third then changes to “The Mind of a Terror Suspect: Could brain chemistry have played role in bombings?”

Tapper raises the issue of whether defense attorneys will use our increased insight into the genetic and neurological underpinnings of harmful behavior to argue that their clients’ actions should be excused. Gupta calls our advancing understanding of the biological roots of crime and violence “an emerging science” and then offers two examples that really highlight the difficulty of assigning appropriate levels of blame to those that commit harmful acts while suffering from certain biological conditions.

• First, Gupta mentions that Fetal Alcohol Syndrome, in which a mother’s drinking during pregnancy harms the developing fetus’ brain, leads that baby in later life to have a much higher likelihood of committing crimes and a nineteen times greater chance than otherwise of ending up in prison.
• Gupta also mentions how a brain tumor can drastically change an otherwise normally-functioning person’s behavior.

This is one of the first times I have seen ponerologic material discussed so explicitly on CNN. However, it isn’t the first. For instance:

• In the wake of the Newtown school shootings, I saw Erin Burnett interview Dr. James Fallon about the biological markers of psychopathy and whether he expected them to be discovered post-mortem in shooter Adam Lanza.

• I also saw a recent segment in which anchor Don Lemon intereviewed criminal profiler Jim Clemente and forensic psychiatrist Helen Morrison about the prevalence of sociopathy. (I tried to find video of this latter segment to share on this site but it seems it was never posted online. However, the transcript of the segment can be found about 1/4 of the way down the page of this transcript of Lemon’s entire show that night.)

But it was really nice to see Sanjay Gupta, who I believe is deservedly highly regarded as a physician, scientist and journalist, covering this topic from a professional and medical perspective. This is the type of coverage I would love to see more of on CNN and similar networks. And I’m glad that I have seen a lot more of it in the past few months than I can remember ever seeing before.

Today’s Wall Street Journal features a sizeable piece by Raine as its “Saturday Essay.”

The title of the essay is “The Criminal Mind” and underneath the title it says “Advances in genetics and neuroscience are revolutionizing our understanding of violent behavior—as well as ideas about how to prevent and punish crime.”

It doesn’t get much more relevant to ponerology than that. And it’s heartening to see Raine given a platform to share his extremely important and provocative ideas in The Wall Street Journal just in advance of the release of his book The Anatomy of Violence: The Biological Roots of Crime.

Raine’s essay touches on:

• The history of criminology as a science and its sometimes unfortunate devolution into pseudoscience
• The rise of neurocriminology
• The roles of genetics, environmental and developmental factors and brain structure and function in the emergence of aggression and antisocial behavior
• The political and social implications of a focus on biological bases for crime
• Recommendations for legal policies that account for our growing ponerologic understanding by both assigning appropriate levels of responsibility to offenders and optimally protecting the rest of society from the threats they pose
• Measures – including some relatively non-invasive ones – that can help significantly reduce the likelihood of harmful behavior in children that display signs of severe aggression

The article is accompanied by the video below. In it, Raine explains the relationship between diminished prefrontal cortex activity and violence, how such prefrontal dysfunction originates and possible treatments for such conditions, as well as how those with normal prefrontal activity but undersized amygdalae can also commit violence in a more planned and calculating fashion.

Raine also offers his opinion in the video about the Tsarnaev brothers who bombed the Boston Marathon.

Most who work in the fields that study aspects of this question take the view that the answer involves some combination of the two.

But this still leaves us with another question. In what proportion do each of these factors contribute in which people?

One remarkable case offers some fascinating insight on the subject.

Dr. James Fallon

James Fallon, Ph.D. is a highly decorated neuroscientist and Professor Emeritus of Anatomy and Neurobiology at University of California, Irvine. Dr. Fallon has several areas of expertise. One is adult stem cells. Another is psychiatry. Specifically, he is interested in the relationships between brain imaging (he has served as Director of UC Irvine’s Human Brain Imaging Center), genetics and various psychiatric conditions, including schizophrenia, depression and addictions.

An Extraordinary Experiment

Aware of his specialties, for many years, Fallon’s colleagues have sent him brain images they wished to have him analyze.

At one point this interchange took the form of an experiment.

Colleagues sent him 70 MRI scans of brains belonging to people ranging from healthy to mentally ill. Included in the batch were scans of brains belonging to killers, including some notorious ones. But Fallon had no idea which scanned brain belonged to whom.

Nonetheless, he was able to identify differences in five of the scans so dramatic that he could recognize them as the markers of psychopathy. And it turned out that he was correct. The five scans on which he zeroed in actually were those from the brains of psychopathic serial killers.

Signs of the Psychopath’s Brain

How could Fallon distinguish the serial killers’ brain scans from the others? He says that all five had some tell-tale signs:

• A lack of activity in the orbital cortex, the brain area just above the eyes, which he says is in the circuit coding for ethics, conscience and impulse control
• A lack of activity in the anterior part of the temporal cortex, where we find the amygdala, a structure deeply involved in processing emotion
• Underfunctioning in the narrow strip of limbic cortices that connect the orbital cortex with the amygdala, namely:
  • The cingulate cortex, which codes for social cues
  • The hippocampal area, which, along with the amygdala, codes for emotional memories
  • The insula, which processes empathy and “gut feelings”

This makes sense. These areas are considered part of the limbic system, the brain complex primarily responsible for our emotional lives. When these areas are underactive or inactive, a person might feel driven – like many killers – to compensate by repeatedly pursuing extreme activities simply to feel satisfied and alive.

Violence-Related Genes

In addition to his study of killers’ brains, Fallon has also studied the genetics of aggression and violence.

Psychological traits are affected by multiple genes. And Fallon says that perhaps a dozen have been identified as high-risk, violence-related genes. These include genes affecting dopamine and norepinephrine neurotransmission and androgen (testosterone) receptors.

The most well-known of these violence-related genes is a particular version of the Monoamine Oxidase A (MAOA) gene. Because it was the first such gene discovered, it was labeled, and has become popularly known as, “the Warrior Gene,” although Fallon stresses that this nickname can be misleading since all of the various genes associated with violence and aggression could be considered, in a sense, warrior genes.

Most humans have an MAOA gene and it helps regulate serotonin, a neurotransmitter that Fallon says helps relax and calm us. But those with the “Warrior Gene” form of it receive too much serotonin during development in utero, which desensitizes the brain to its effects. That means that later in life, when serotonin would otherwise inhibit behavior, it is unable to do so, resulting in impulsivity and violence.

The MAOA gene is on the X chromosome. This has important implications for how its effects express themselves in males vs. females. Girls get an X chromosome from both their mother and father, so even if one parent passes along the “Warrior Gene” variant, they are likely to get a normally functional MAOA variant from the other parent that offsets its potentially dangerous consequences. But boys get only one X chromosome – the one passed down from their mother. If that X chromosome has the “Warrior” version of the MAOA gene, that will be the only version of it that the boy receives.

This means that violence related to the MAOA “Warrior Gene” is usually passed genetically from mother to son. Fallon believes it also explains why boys and men are much more likely to be very aggressive or psychopathic killers.

Moreover, Fallon says that the reduced empathy seen in psychopathy may be associated with the influence of low acting genes related to the hormones oxytocin and vasopressin.

Can Biology Alone Create a Psychopath?

So, putting this together, Fallon recognized patterns in both the brains and genetics of psychopathic killers.

1. Loss of function in the orbital cortex, anterior temporal lobes and the strip of limbic cortices connecting the two
2. Having one or more of several high-risk, violence-related genes (like the so-called “Warrior Gene”)

But a crucial question remained. Are these biological markers alone enough to create a psychopath?

Fallon suspected not. But little did he know that he would receive some validation for this suspicion from so close to home.

A Shocking Fallon Family Pattern is Revealed

Based on his work, Fallon was giving many presentations about psychopathic killers. His mother said that, since he was doing this, he should probably know about the release of a new book called Killed Strangely: The Death of Rebecca Cornell.

The Cornells, you see, were direct ancestors of Fallon’s father. One of them, for instance, was Ezra Cornell, the founder of Cornell University. But Killed Strangely is about another, more sinister Cornell: Thomas Cornell, who killed his mother, Rebecca, and was hanged for it in 1673, the first case of matricide, Fallon says, recorded in the new American colonies.

Investigating further, Fallon discovered that the rabbit hole went even deeper. There were actually seven murders committed by those within his father’s family line. This line also included Lizzie Borden, his cousin, who was controversially acquitted of killing her father and stepmother with an axe in 1892.

Testing Enlightens the Fallons

After learning of his family’s bloody history, James Fallon decided to have brain imaging – PET scans and EEG’s – as well as genetic analyses carried out on himself and nine family members, including his parents, wife and children, to see if any had the markings of killers.

The results:

• All of the images of the family members’ brains were normal when analyzed for markers of potential violence…except for the images of one, Fallon’s own. His scan looked identical to those of the serial killers he had studied, with a malfunctioning limbic system lacking activity in the orbital cortex, anterior temporal lobes and areas connecting them.
• The entire family exhibited a typical mix of genes related to aggression, impulsivity and other relevant traits…except one member. Fallon himself not only had high-risk genes associated with violence, but he had far more of them than many psychopaths and killers. In fact, he says, he had almost all of them.

His family’s reaction to these results is quite interesting:

His son said that he always knew there was something “off” about his father and that, at times, he had feared him because he is a “hothead” with all the traits you’d expect in a serial killer. He said this makes more sense now that he knows that his father has the brain and genetics of a psychopath.

Fallon’s wife said the results were surprising, yet not surprising because he is, in a way, two people, with a funny, gregarious side mixed with a standoffish side.

James Fallon himself does admit to some macabre interests, a predilection for risk-taking and a superficial charm, which you might see in psychopaths and murderers. And he also admits he may sometimes be drawn to behavior that he knows is wrong but “still doesn’t care.”

The Third Ingredient

But, however imperfect, James Fallon is not violent or a killer. And this has enormous implications.

How is it that, despite having so many biological markers for violence, Fallon ended up a scholar rather than an aggressor or even a murderer?

Fallon has come to believe that, in addition to particular brain and genetic patterns, there is a third ingredient involved in the development of a violent psychopath. The environment, he explains, can help determine whether violence-related genes and certain brain processes, such as those involving mirror neurons, are triggered towards aggression. Specifically, he believes that abuse – especially severe early childhood sexual, physical or emotional abuse – is instrumental in this process. And he also believes that the precise timing of when various factors come into play is critically important in determining whether one becomes a psychopath and, if so, exactly what type of psychopathological behavior is exhibited.

As for why he himself is not a violent man, Dr. Fallon credits his upbringing in a highly nurturing environment, in which he was not only not abused, but was showered with wonderfully loving family support.

Some of Dr. James Fallon’s Appearances

Fallon has spoken on these topics in a number of forums, including:

• This television interview
• A TED talk entitled “Jim Fallon: Exploring the mind of a killer”Here, Fallon talks about his research and his story.

  He also gives a brief synopsis of a talk he did in Israel about his theory of transgenerational, sex-linked violence in perpetually conflicted world regions. His theory is that severe trauma before the onset of puberty triggers violent expression in those with violence-related genes such as, for example, the “Warrior” version of the MAOA gene. When this happens frequently in an area, the environment becomes increasingly threatening, so aggressive men, capable of physical protection and more likely to carry these genes, become more and more attractive to females. In consequence, violence-related genes become relatively highly concentrated in the population’s gene pool, sparking a vicious cycle.

  This theory is consistent with a similar, somewhat stunning, phenomenon that I discussed in my own writings on psychopathy.

• An episode of Reason TV called “Three Ingredients for Murder: Neuroscientist James Fallon on Psychopaths and Libertarians”Here, in addition to sharing his story, Fallon discusses the implications of work like his for our views of free will and responsibility, as well as for our legal system, especially in regards to psychopaths. He also discusses how our increasing ability to recognize each person’s unique makeup will challenge our capacity for creating standards in public policy and drive us toward individualized medicine. And he explains why he is a libertarian and how that may correlate with the function and/or lack of function in certain brain areas.

• A September 2011 episode of the BBC program Horizon entitled “Are You Good or Evil?”In these clips from the show, Fallon talks about his research on the brain scans of murderers, the tests carried out on him and his family and his discovery that his results showed the brain and genetic patterns seen in psychopathy.

  The first video also contains a quote that I found very powerful which serves to crystallize Fallon’s study of killers:

  It really indicated that there was a biological basis – a really hardcore brain basis – for this urge to kill.

  
  The second video includes the comments about his personality attributed earlier to his son and his wife.

• A segment called “Confessions of a Pro-Social Psychopath” produced by the World Science Festival in conjunction with The Moth, a non-profit that promotes storytelling.The title of this talk grabbed me because I had often wondered whether there could be “pro-social psychopaths,” but I had never heard the term used elsewhere. I also found this to be a nice overall telling of his story by Fallon.

Dr. Fallon also appeared on a November 18, 2009 episode of Criminal Minds, the CBS drama about FBI profilers. In the episode, which was based on his TED talk, he played himself giving a lecture about his theory of transgenerational violence in areas of conflict, which was mentioned earlier.

What Fallon May Tell Us About a Possible Future with Less Psychopaths and Killers

What are the implications of Fallon’s research and his story for society at large?

Well, there are some conditions for which we screen early in life. If we detect that a person has or is at risk for such a condition, we can then intervene in time to prevent or best manage it.

A good example is phenylketonuria (PKU). This is a genetic disorder in which an enzyme needed to properly metabolize a particular amino acid, phenylalanine, is rendered nonfunctional. As a result, a person with PKU who eats a normal diet can experience severe consequences including mental retardation.

Luckily, in most countries, newborns are screened for PKU. If it is detected, they can be put on a special diet in which phenylalanine is restricted and special supplements are provided. As a result, the person with PKU can live a normal, healthy life.

Fallon’s case raises the possibility that, as advocated by Adrian Raine, we may someday be able to screen children for a predisposition to psychopathy and, when they are identified as at-risk, intervene with special measures to prevent or best manage the development of violent or other dangerous propensities in at least some of them. Further research could be done to more specifically identify the types of measures that bring about the healthiest outcomes for such individuals and those around them. But it’s likely that these would include conscientious provision, throughout these youngsters’ upbringings, of the abundance of love and care for which Fallon credits his own nonviolent lifestyle.

In other words, we may someday see a future when all, or at least at-risk, families will be tested for the markers of violence just the way Fallon’s was so that those who do have the brains and genes we find in psychopaths can more often develop into, say, professors like James Fallon rather than killers like too many others – including some of those he has studied for a living and quite a few of his recent ancestors.